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Table 3 Univariate analysis of local tumor control and overall survival (log rank of Kaplan-Meier method)

From: Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma

Characteristic Patients, No. Local
control
Overall survival
    Χ 2 P Χ 2 P
Gender Male 32 1.054 0.305 2.671 0.102
  Female 11     
Age ≤70 23 0.832 0.362 0.116 0.733
  >70 20     
Karnofsky performance status 70 7 1.584 0.453 1.769 0.413
  80 19     
  90 17     
Comorbidities Yes 33 0.442 0.506 0.007 0.932
  No 10     
Type Central 8 0.427 0.514 0.173 0.678
  Periphery 35     
Histology Squamous cell carcinoma 17 0.696 0.874 0.975 0.807
  Adenocarcinoma 14     
  Adenosquamouscarcinoma 1     
  Unspecified 11     
Clinical stage I 23 14.888 0.000 7.926 0.005
  II 20     
Tumor size ≤3 cm 4 12.824 0.005* 5.361 0.147
  3-5 cm 20     
  5-7 cm 10     
  >7 cm 9     
Dose/fraction
(50% isodose line)
<6Gy 27 1.337 0.248 0.979 0.322
  ≥6Gy 16     
BED (50% isodose line) <60Gy 17 0.550 0.458 0.033 0.856
  ≥60Gy 26     
Chemotherapy no 30 2.194 0.139 6.000 0.014
  yes 13     
  1. Abbreviation: BED: biological effective dose.
  2. *: pairwise comparisons of local control of different size tumors.