Figure 3

Bio-distribution of ¹⁰B in mice with normal liver or with liver tumors. A) Time course of organ (lung, liver, kidney, and spleen) uptake of ¹⁰B delivered by 1.2 μg boron/g of BSH or CG-HVJ-E-BSH in normal mice. B) Time course of tumor accumulation (left panel), liver uptake (middle panel), and blood residence (right panel) of ¹⁰B delivered by 1.2 μg boron/g of BSH or CG-HVJ-E-BSH in tumor-bearing mice. The horizontal axis shows the time after administration. The vertical axis shows the percent of the administered dose per gram of tissue (% dose/g). C) Time course of the Tumor-to-Normal liver tissue (T/N) ¹⁰B concentration ratio for CG-HVJ-E-BSH (open diamond) or BSH solution (solid square). Data are expressed as the mean ± S.D. (n = 3). * p < 0.05 compared with BSH.