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Figure 4 | Radiation Oncology

Figure 4

From: Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response

Figure 4

Apoptotic effects of BO-1051 in combination with irradiation in glioma cells. U87MG, U251MG and GBM-3 were exposed to 200 nM or higher concentration (1200 nM) of BO-1051 for 24 h and irradiated with 2 Gy, followed by FACS analysis of Annexin V-FITC and PI staining 24 h later. Control: no treatment; IR: ionizing radiation at 2 Gy; BO: BO-1051; BO+IR: cells exposed to BO-1051 for 24 h and then irradiation with 2 Gy of γ-ray. Values are the means ± SD of 3 independent experiments. * p < 0.05.

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