Figure 4

A Volume Surrogate. A previously published measure of intra-tumoral heterogeneity is plotted versus tumor volume for patients who underwent successful (circles) or unsuccessful (triangles) therapy. Observe that the heterogeneity measure is directly proportional to volume and there is a lack of clustering of patients into distinct groups with differing disease outcome. As seen in the inset, the trend persists over three orders of magnitude. The inset axes have the same units as in the primary plot.