Skip to main content

Table 1 Results of Growth Delay Assays

From: Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study

Schedule

Time in days for tumors to grow from 200 to 600 mm3

Growth-AGD††

Delay NGD§

Endhancement Factorǁ

Allografts

    

Control

8.8 ± 0.9

-

  

PTK787

10.5 ± 0.5

1.7

-

-

IR

17.2 ± 0.5

8.4

-

-

PTK787+IR

22.8 ± 1.4

14.0

12.3

1.5

Spontanous Tumors

    

Control

11.5 ± 0.8

-

-

-

PTK787

14.3 ± 1.5

2.8

-

-

IR

31.6 ± 2.8

20.1

-

 

PTK787+IR

41.9 ± 1.8

30.4

27.6

1.4

  1. Effect of PTK787 on the radioresponse of allograft and spontaenous tumors measured by tumor growth delay. For treatment schedules see Figure 1.
  2. ††Absolute tumor growth delay (AGD) caused by PTK787, IR, or their combination is defined as the time in days required for tumor to triple tumor size from 200 to 600 mm3 minus the time in days in untreated tumors.
  3. §Normalized tumor growth delay (NGD) is defined as the time in days for tumors to triple tumor size in the mice treated with the combination of PTK787 and IR minus the time in days to triple tumor size in mice treated with PTK787 alone.
  4. ǁEnhancement factors obtained by dividing NGD in mice treated with PTK787 plus IR by the AGD in mice treated with IR alone.
Back to article page

Radiation Oncology

ISSN: 1748-717X

Contact us