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Table 5 Univariate analysis for grades 3-4 late subcutaneous toxicity in the whole series of patients (n = 26) and in patients who received higher doses of RT (n = 19)

From: Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy

 

HR

(95% CI)

P

Whole series

   

   Age

1.012

(0.975-1.012)

0.535

   Received dose

1.079

(0.980-1.189)

0.123

   Maximum dose

1.054

(0.991-1.121)

0.096

   Bra size

1.056

(1.003-1.111)

0.037

   Systemic treatment

1.084

(0.351-3.347)

0.888

   Low DSB-High RIA 1Gy

0.564

(0.233-1.370)

0.206

   Low DSB-High RIA 2Gy

0.510

(0.204-1.277)

0.150

   Low DSB-High RIA 8Gy

0.642

(0.270-1.523)

0.314

Higher dose (≥81.6Gy)

   

   Low DSB-High RIA 1Gy

0.252

(0.077-0.826)

0.023

   Low DSB-High RIA 2Gy

0.197

(0.053-0.735)

0.016

   Low DSB-High RIA 8Gy

0.240

(0.074-0.778)

0.017

  1. Abbreviations: HR = hazard ratio; CI = confidence interval
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Radiation Oncology

ISSN: 1748-717X

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