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Table 6 Calculated tumor BED (Gy15), acute mucosal BED (Gy10) and late normal tissue BED (Gy3) for common radiation schedules

From: Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons

Dose size (Gy) Fraction number Total dose (Gy) Overall treatment time (OTT) in days Tumor BED (Gy15) Acute Mucosal BED (Gy10) (aim 59-63 Gy10)[46] Late normal BED (Gy3) (aim <117 Gy3)[46] references
2.0 33 66 45 64.60 49.1 110 [22, 25, 27] & current study
2.25 28 63 38 66.45 52.62 110.2 [3, 5, 20, 24, 37]
2.5 23 57.5 31 65.28 52.87 105.4 current study
  1. BED = biologically effective dose
  2. = total dose (1 + fraction size/[α/β]) - loge 2 (OTT -T k)/αT p [14]
  3. Assume: 1. α/β = 15 for laryngeal cancer [12]
  4. 2. T k: kick off time (T k) for tumor repopulation = 28 days [13]
  5. 3. T p = average cell number doubling time during continuing radiation, 3 days for tumor [14]
  6. 4. Alpha (α) = [coefficient of non-repairable injury, log cell kill (exponentially-based logs) per gray of dose]
  7. = 0.35 Gy-1 (14)]