Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons

Table 2 Univariate and multivariate analysis of factors affecting local control

Parameters	Events/patients	Uni-variate analysis	Multivariate analysis
		P value	HR (95% CI)	P value
Age
<61	18/142
61-70	15/153	0.302	_	_
>70	9/138
Sex
Male	41/413	0.445	_	_
Female	1/20
Sub-stage
T1A	28/324	0.24	_	_
T1B	14/109
Grade
Well diff	9/154		1
Mod diff	29/273	0.0001*	1.91 (1.2-3.85)	0.035*
Poorly diff	4/6		7.5 (3.42-15.24)
Hb
< 13.0	6/45	0.367	_	_
≥ 13.0	36/388
AC
No	14/236	0.004*	1	0.011*
Yes	28/197		2.34 (1.21-4.52)
Field size (cm²)
<30.5	35/215
30.5-35.5	7/165	0.534	_	_
> 35.5	0/53
Dose size
2.0 Gy	32/256	0.021*	2.17 (1.28-4.18)	0.035*
2.5 Gy	10/177		1
Tumor BED
< 65 (Gy₁₅)	29/239	0.025*	3.38 (1.29-7.83)	0.017*
≥ 65 (Gy₁₅)	13/194		1
Tx period
1983-1990	10/115
1991-2000	25/224	0.643	_	_
2001-2005	7/94

Abbreviations: HR = Hazard ratio; CI = confidence interval; Gy = Gray;
diff = differentiated; AC = anterior commissure; BED = Biologically Effective Dose;
* = statistically significant

ISSN: 1748-717X