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Table 2 Univariate and multivariate analysis of factors affecting local control

From: Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons

Parameters Events/patients Uni-variate analysis Multivariate analysis
   P value HR (95% CI) P value
Age     
<61 18/142    
61-70 15/153 0.302 _ _
>70 9/138    
Sex     
Male 41/413 0.445 _ _
Female 1/20    
Sub-stage     
T1A 28/324 0.24 _ _
T1B 14/109    
Grade     
Well diff 9/154   1  
Mod diff 29/273 0.0001* 1.91 (1.2-3.85) 0.035*
Poorly diff 4/6   7.5 (3.42-15.24)  
Hb     
< 13.0 6/45 0.367 _ _
≥ 13.0 36/388    
AC     
No 14/236 0.004* 1 0.011*
Yes 28/197   2.34 (1.21-4.52)  
Field size (cm2)     
<30.5 35/215    
30.5-35.5 7/165 0.534 _ _
> 35.5 0/53    
Dose size     
2.0 Gy 32/256 0.021* 2.17 (1.28-4.18) 0.035*
2.5 Gy 10/177   1  
Tumor BED     
< 65 (Gy15) 29/239 0.025* 3.38 (1.29-7.83) 0.017*
≥ 65 (Gy15) 13/194   1  
Tx period     
1983-1990 10/115    
1991-2000 25/224 0.643 _ _
2001-2005 7/94    
  1. Abbreviations: HR = Hazard ratio; CI = confidence interval; Gy = Gray;
  2. diff = differentiated; AC = anterior commissure; BED = Biologically Effective Dose;
  3. * = statistically significant