Skip to main content

Table 3 Patient characteristics between the surgery plus chemoradiation and chemoradiation alone groups

From: Clinical outcomes of chemoradiotherapy for locally recurrent rectal cancer

Characteristic Surgery + chemoradiation (n= 45) chemoradiation (n= 22) P
Mean age, years 56.7 ± 11.5 60.0 ± 13.4 0.377§
Gender    
   Male 25 15 0.322†
   Female 20 7  
Recurrence-free interval, months 35.3 30.0 0.521§
Chemotherapy history    
   Yes 35 20 0.310‡
   No 10 2  
Radiation history    
   Yes 14 6 0.747†
   No 31 16  
Recurrence history    
   0 35 16 0.649†
   1 10 6  
Symptoms at recurrence    
   Yes 9 11 0.014†
   no 36 11  
Recurrence site    
   Central 16 5 0.440†
   Lateral 20 10  
   posterior 9 7  
Pretreatment CEA (ng/mL)    
   ≤5 30 7 0.009†
   >5 15 15  
Chemotherapy regimen    
   Fluoropyrimidines alone 21 13 0.249†
   Irinotecan or oxaliplatin-based 24 8  
Radiation dose (BED2Gy)    
   <60 34 1 <0.001†
   ≥60 11 21  
Mean radiation dose, BED2Gy 54.6 ± 5.5 66.5 ± 6.2 <0.001§
  1. †chi-squared test; ‡ Fisher exact test; § t-test; BED2Gy, biologically equivalent dose in 2-Gy fractions using a linear quadratic model, CEA, carcinoembryonic antigen; and the α/β; ratio was 10 for acute effects on normal tissues and tumors.