Clinical outcomes of chemoradiotherapy for locally recurrent rectal cancer

Radiation Oncology

Table 3 Patient characteristics between the surgery plus chemoradiation and chemoradiation alone groups

Characteristic	Surgery + chemoradiation (n= 45)	chemoradiation (n= 22)	P
Mean age, years	56.7 ± 11.5	60.0 ± 13.4	0.377§
Gender
Male	25	15	0.322†
Female	20	7
Recurrence-free interval, months	35.3	30.0	0.521§
Chemotherapy history
Yes	35	20	0.310‡
No	10	2
Radiation history
Yes	14	6	0.747†
No	31	16
Recurrence history
0	35	16	0.649†
1	10	6
Symptoms at recurrence
Yes	9	11	0.014†
no	36	11
Recurrence site
Central	16	5	0.440†
Lateral	20	10
posterior	9	7
Pretreatment CEA (ng/mL)
≤5	30	7	0.009†
>5	15	15
Chemotherapy regimen
Fluoropyrimidines alone	21	13	0.249†
Irinotecan or oxaliplatin-based	24	8
Radiation dose (BED_2Gy)
<60	34	1	<0.001†
≥60	11	21
Mean radiation dose, BED_2Gy	54.6 ± 5.5	66.5 ± 6.2	<0.001§

†chi-squared test; ‡ Fisher exact test; § t-test; BED_2Gy, biologically equivalent dose in 2-Gy fractions using a linear quadratic model, CEA, carcinoembryonic antigen; and the α/β; ratio was 10 for acute effects on normal tissues and tumors.

ISSN: 1748-717X