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Table 1 Patient and treatment characteristics

From: The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer

Characteristic

Lower BED Group (≤57 Gy)

Higher BED Group (>57 Gy)

P

Patients(n)

70

135

 

Age(years)

   

Median

62

60

0.574

Range

38-83

35-81

 

Gender

  

0.713

Male

57(81.4)*

107(79.3)

 

Female

13(18.6)

28(20.7)

 

KPS

   

Median

80

80

0.163

Range

60-100

60-100

 

Weight loss>5%

  

0.178

Yes

21(30.0)

29(21.5)

 

No

49(70.0)

106(78.5)

 

LDH

  

0.517

≤220 IU/L

35(43.1)

34(35.3)

 

>220 IU/L

25(26.4)

78(22.6)

 

Unknown

10(30.5)

23(42.1)

 

ISN

  

0.190

Yes

8(11.4)

25(18.5)

 

No

62(88.6)

110(81.5)

 

CHT cycles

  

0.620

Median

4

6

 

Range

3-8

3-7

 

SER

  

0.951

Median

81

72

 

Range

34-262

30-236

 

BED(Gy)

  

0.000

Median

53.6

58.5

 

Range

41.3-56.9

57.1-66.1

 

TRT fractions

  

0.000

Once-daily

52(74.3)

23(17.0)

 

Twice-daily

18(25.7)

112(83.0)

 

TRT technique

  

0.418

2D

52(74.3)

107(79.3)

 

3D

18(25.7)

28(20.7)

 

Size of TRT field(cm3)#

  

0.722

Median

132

137

 

Range

54-210

46-228

 

PCI

  

0.199

Yes

11(15.7)

13(9.6)

 

No

59(84.3)

122(90.4)

 
  1. * Data in parentheses are percentages.
  2. # The size of equivalent square field at anterior-posterior axis
  3. Abbreviations: BED = biologically effective dose with time correction; KPS = Karnofsky performance score; LDH = lactate dehydrogenase; ISN = ipsilateral supraclavicular nodes; CHT = chemotherapy; SER = the time from the start of any treatment to the end of chest irradiation; TRT = thoracic radiation therapy; 2D = 2 dimension; 3D = 3 dimension; PCI = prophylactic cranial irradiation.