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Table 1 Correlation between clinical and pathological factors and CR

From: Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer

Histological response

 

Non-CR

CR

Univariate

Multivariate

    

p-value

p-value

Age

 

63.6 ± 10.6

60.8 ± 9.6

NS

 

Sex

M

25

4

NS

 
 

F

15

4

  

Tumor Size

≥4 cm

21

1

0.043

0.127

 

<4 cm

19

7

  

Circumferential tumor extent

≥60%

21

1

0.043

 
 

<60%

19

7

  

Distance from anal verge

≥5 cm

15

5

NS

 
 

<5 cm

25

3

  

T stage

2

12

1

NS

 
 

≥3

28

7

  

N stage

0

26

7

NS

 
 

1

14

1

  

M stage

0

38

8

NS

 
 

1

2

0

  

Serum level of CEA

≥5 ng/ml

20

5

NS

 
 

<5 ng/ml

20

3

  

CD4 density

≥78

17

7

0.015

 
 

<78

23

1

  

CD8 density

≥54

17

7

0.015

0.0072

 

<54

23

1

  
  1. NS: not significant
  2. Size was determined by CT scan, and circumferential extent and distance from anal verge by colonoscopy. Histological grade was determined by Japanese criteria for colorectal carcinoma.