Skip to main content

Table 1 Correlation between clinical and pathological factors and CR

From: Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer

Histological response   Non-CR CR Univariate Multivariate
     p-value p-value
Age   63.6 ± 10.6 60.8 ± 9.6 NS  
Sex M 25 4 NS  
  F 15 4   
Tumor Size ≥4 cm 21 1 0.043 0.127
  <4 cm 19 7   
Circumferential tumor extent ≥60% 21 1 0.043  
  <60% 19 7   
Distance from anal verge ≥5 cm 15 5 NS  
  <5 cm 25 3   
T stage 2 12 1 NS  
  ≥3 28 7   
N stage 0 26 7 NS  
  1 14 1   
M stage 0 38 8 NS  
  1 2 0   
Serum level of CEA ≥5 ng/ml 20 5 NS  
  <5 ng/ml 20 3   
CD4 density ≥78 17 7 0.015  
  <78 23 1   
CD8 density ≥54 17 7 0.015 0.0072
  <54 23 1   
  1. NS: not significant
  2. Size was determined by CT scan, and circumferential extent and distance from anal verge by colonoscopy. Histological grade was determined by Japanese criteria for colorectal carcinoma.