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Table 3 Enriched gene ontology terms for genes down-regulated in bleomycin sulphate treated fibroblasts compared to controls.

From: Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients

Gene ontology term

a Number of genes

b EASE score

Cell cycle

82

6.00E-16

Mitotic cell cycle

40

4.27E-15

Mitosis

33

2.77E-14

M phase of mitotic cell cycle

33

4.09E-14

M phase

36

4.38E-13

Cell division

34

7.07E-13

DNA metabolism

72

1.36E-12

Biopolymer metabolism

196

2.85E-12

Cellular physiological process

537

2.60E-11

DNA replication

33

1.52E-10

Regulation of progression through cell cycle

53

2.42E-10

Regulation of cell cycle

53

2.65E-10

Nucleobase, nucleoside, nucleotide and nucleic acid metabolism

219

1.93E-09

Spindle organization and biogenesis

11

4.02E-09

Response to DNA damage stimulus

34

1.73E-08

Response to endogenous stimulus

35

2.45E-08

Primary metabolism

395

5.41E-08

DNA-dependent DNA replication

19

5.68E-08

DNA repair

31

6.80E-08

Macromolecule metabolism

265

1.18E-07

  1. All 16 fibroblast samples were included in the analysis. The top 20 terms for genes down-regulated after bleomycin sulphate are shown.
  2. aThe number of genes involved in the term are shown.
  3. bThe modified Fisher Exact p value (EASE score) is shown. The smaller the score, the more highly enriched the category.