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Table 3 Summary of main results on published studies on the conformal radiotherapy and FSRT of skull base meningiomas

From: Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas

authors

Patients

(n)

Technique

(%)

Volume

(ml)

Dose

(Gy)

Follow-up

(months)

Local control

(%)

Late toxicity

(%)

Goldsmith et al., 1994

117

CRT

NA

54

40

89 at 5 and 77 at 10 years

3.6

Maire et al., 1995

91

CRT

NA

52

40

94

6.5

Peele et al., 1996

42

CRT

NA

55

48

100

5

Condra et al.,1997

28

CRT

NA

53.3

98

87 at 15 years

24

Connell et al., 1999

54

CRT

NA

54

55

76 at 5 years

19

Maguire et al., 1999

26

CRT

NA

53

41

8 at 8 years

8

Nutting et al., 1999

82

CRT

NA

55-60

41

92 at 5 and 83 at 10 years

14

Vendrely et al., 1999

156

CRT

NA

50

40

79 at 5 years

11.5

Dufour et al., 2001

31

CRT

NA

52

73

93 at 5 and 10 years

3.2

Pourel et al., 2001

28

CRT

NA

56

30

95 at 5 years

4

Mendenhall et al., 2003

101

CRT

NA

54

64

95 at 5, 92 at 10 and 15 years

8

Debus et al., 2001

189

FSRT

52.5

56.8

35

97.3

1.6

Jalali et al., 2002

41*

FSRT

17.9

55

21

100

12.1

Lo et al., 2002

18*

FSRT

8.8

54

30.5

93.3

5

Torres et al., 2003

77*

FSRT

16.1

48.4

24

97.2

5.2

Selch et al., 2004

45

FSRT

14.5

56

36

100 at 3 years

0

Milker-Zabel et al., 2005

317*

FSRT

33.6

57.6

67

90.5 at 5 and 89 at 10 years

8.2

Henzel et al., 2006

84

FSRT

11.1

56

30

100

NA

Brell et al., 2006

30

FSRT

11.3

52

50

93 at 4 years

6.6

Hamm et al., 2008

183

FSRT

27.4

56

36

97 at 5 years

8.2

Litré et al., 2009

100

FSRT

NA

45

33

94 at 3 years

0

Metellus et al., 2010

47

FSRT

12.6

52.9

82.8

98 at 5 and 96 at 10 years

2.6

Tanzler E et al., 2010

144**

FSRT

NA

52.7

96

97 at 5 and 96 at 10 years

7

  1. CRT, conformal 3-D radiotherapy; FSRT, fractionated stereotactic radiotherapy
  2. *Series include some patients with intracranial meningiomas
  3. ** 41 patients received CRT