Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy?

Table 4 The impact of clinical and pathologic factors on the overall survival

Factors Assessed	Univariate Analysis			Multivariate Analysis
	Hazard Ratio	95% CI^a	p^b	Hazard Ratio	95% CI	p^c
Age
≤50 (vs >50)	0.947	0.32-2.80	0.922
Menauposal status
No (vs yes)	0.966	0.33-2.87	0.951
Histologic grade
3 (vs, 1-2)	1.108	0.36-3.39	1.000
Nuclear grade
3 (vs 1-2)	1.037	0.30-3.62	0.859
Lymphatic invasion
Yes (vs absent)	3.955	0.78-11.3	0.022	3.052	0.98-9.87	0.021
Vascular invasion
Yes (vs absent)	1.631	0.46-5.82	0.547
Perineural invasion
Yes (vs absent)	1.771	0.56-5.60	0.409
Tumor size
2.1-5 cm (vs ≤2 cm)	3.323	1.34-12.1	0.013	1.865	1.21-11.8	1.124
Estrogen receptor
Negative (vs positive)	1.717	0.44-6.65	0.115
Progesteron receptor
Negative (vs positive)	2.120	0.68-15.35	0.102
Ratio of positive lymph node
≥25% (vs <25%)	3.471	1.14-10.57	0.001	2.139	1.28-11.21	1.239
Hormonothreapy
No (vs yes)	2.819	0.91-8.75	0.110
Postoperative radiotherapy
No (vs yes)	2.143	1.22-17.95	0.087	1.253	1.18-16.13	1.124
Event
Yes (vs absent)	4.743	1.70-7.28	0.008	2.511	1.74-6.93	0.0812
Local failure
Yes (vs absent)	3.462	0.99-30.08	0.067	1.242	1.12-23.7	1.318
Distant metastasis
Yes (vs absent)	3.667	1.85-7.26	0.00	5.437	1.92-8.13	0.000

^a Confidence interval, ^b Kaplan-Meier analysis (log-rank test), ^c Cox regression analysis.

ISSN: 1748-717X