Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series

See, Alfred P; Zeng, Jing; Tran, Phuoc T; Lim, Michael

doi:10.1186/1748-717X-6-25

Table 1 Baseline data: patients receiving concurrent protease inhibitor

From: Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series

#	Cancer diagnosis	Age	Concurrent systemic therapy	Baseline CD4	Non-PI HIV regimen	PI
1a	Ductal carcinoma, breast T2N1M0	47	None	104	lamivudine, raltegravir	RTV, DRV
1b	SCC, anus T3N0M0	49	5-FU, mitomycin C	68	lamivudine, raltegravir	RTV, DRV
2	SCC, vulva T1bN1b, stage IIIa	26	cisplatin	1647	emtricitabine, tenofovir	RTV, ATZ
3	Ductal carcinoma, breast T1cN0M0, stage I	47	None	474	emtricitabine, tenofovir, raltegravir	RTV, ATZ
4	SCC, anus T2N0M0, stage II	47	None	NR	emtricitabine, tenofovir, raltegravir	RTV, DRV
5	Adenocarcinoma, prostate cT2bNXM0, GS 3+3, PSA 8.7, stage II	58	None	WNL	efavirenz, emtricitabine, tenofovir	RTV, LPV
6	Adenocarcinoma, prostate cT1cNXM0, GS 3+4, PSA 4.9, stage II	73	androgen deprivation	1105	raltegravir	RTV, DRV
7	Adenocarcinoma, prostate cT1cNXM0, GS 4+3, PSA 5.1stage II	69	androgen deprivation	536	abacavir, lamivudine	RTV, ATZ
8	Renal cell carcinoma, lateral chest wall, metastatic, stage IV	50	sutent	766	emtricitabine, tenofovir, efavirenz	RTV, ATZ
9	Arteriovenous fistula, dura mater	57	None	944	abacavir, lamivudine, raltegravir	RTV, LPV
10	SCC, tonsil T2N2bM0	53	cisplatin	956	emtricitabine, tenofovir	RTV, LPV
11	Primary CNS lymphoma, CNS	44	None	4	None	RTV, DRV
			doxil, cytoxan,
12	NHL, neck and axilla, stage IV	53	vincristine, prednisone	57	abacavir, lamivudine	RTV
13a	NHL, pelvis, stage IV	53	None	120	abacavir, lamivudine	RTV, ATZ
13b	NHL, axilla, stage IV	55	None	39	abacavir, lamivudine	RTV, LPV
13c	NHL, temple, stage IV	56	None	87	abacavir, lamivudine	RTV, LPV
14	Primary CNS lymphoma, CNS	21	None	0	emtricitabine, tenofovir	RTV, DRV
15	Ductal carcinoma, breast T2N0M0, stage IIa	58	None	NR	emtricitabine, tenofovir	RTV, LPV
16	SCC, anus T1N0M0, stage I	43	5-FU, mitomycin C	547	abacavir, lamivudine	RTV, LPV
17	Primary CNS lymphoma, CNS	23	None	10	emtricitabine, tenofovir	RTV, DRV
18	Keloid scar, posterior scalp	47	None	WNL	zidovudine 300 mg, lamivudine 150 mg	NFV

Patients are uniquely identified by numbers, repeated treatments on a patient are distinguished by a letter after the number.
NHL = non-Hodgkin lymphoma
cT = clinical tumor, pT = pathological tumor, GS = Gleason score, PSA = prostate specific antigen
RTV = ritonavir, DRV = darunavir, ATZ = atazanavir, LPV = lopinavir, NFV = nelfinavir
WNL = Reported as within normal limits, NR = not reported

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ISSN: 1748-717X

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