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Table 5 Univariate and multivariate analyses for overall survival

From: Validation of the new graded prognostic assessment scale for brain metastases: a multicenter prospective study

 

Univariate

Multivariate

   

95% CI

  

95% CI

Variable

P

HR

Low

High

P

HR

Low

High

KPS *

        

   ≤ 60

< 0.001

1

  

< 0.001

1

  

   70-80

0.03

0.69

0.50

0.96

0.04

0.70

0.49

0.99

   ≥ 90

< 0.001

0.35

0.23

0.55

< 0.001

0.40

0.25

0.65

Center *

        

   1

 

1

   

1

  

   2

< 0.001

0.50

0.35

0.71

0.007

0.59

0.41

0.87

Number of BM *

        

   > 3

0.04

1

  

0.59

1

  

   2 - 3

0.11

0.77

0.55

1.07

0.52

0.89

0.63

1.27

   1

0.02

0.64

0.45

0.92

0.33

0.83

0.57

1.21

Primary Tumor *

        

   Breast

0.05

1

  

0.08

1

  

   Lung

0.02

1.59

1.08

2.36

0.04

1.57

1.02

2.41

   Other

0.12

1.41

0.92

2.18

0.06

1.55

0.98

2.45

Control Primary *

        

   NED or SD

 

1

   

1

  

   PD

0.04

1.34

1.01

1.79

0.17

1.24

0.91

1.7

ExCr *

        

   No

 

1

   

1

  

   Yes

0.03

1.41

1.03

1.92

0.26

1.22

0.86

1.74

Age *

        

   ≥ 60

0.97

1

  

0.54

1

  

   50-59

0.81

0.96

0.69

1.34

0.79

0.95

0.67

1.36

   < 50

0.92

0.98

0.68

1.41

0.35

1.21

0.81

1.82

RPA **

        

   I

0.002

1

  

0.02

1

  

   II

0.44

1.19

0.77

1.84

0.51

1.16

0.74

1.82

   III

0.003

2.08

1.29

3.35

0.01

1.91

0.16

3.14

GPA ***

        

   3.5 - 4

0.001

1

  

0.03

1

  

   3

0.75

1.23

0.33

4.57

0.79

1.19

0.32

4.43

   1.5 - 2.5

0.32

1.80

0.57

5.69

0.42

1.62

0.51

5.16

   0 - 1

0.07

2.95

0.93

9.34

0.14

2.40

0.74

7.74

BSBM ****

        

   3

< 0.001

1

  

< 0.001

1

  

   2

0.39

0.81

0.50

1.31

0.18

0.71

0.43

1.17

   1

0.34

1.25

0.79

1.96

0.70

1.10

0.68

1.78

   0

0.002

2.13

1.32

3.44

0.01

1.96

1.17

3.27

  1. Abbreviations: KPS, Karnofsky performance status; BSBM, Basic Score for Brain Metastasis; RPA, Recursive Partitioning Analysis; GPA, Graded Prognostic Assessment; BM, Brain Metastasis; ExCr, Extra-cranial metastatic disease.
  2. *: regression model with centers, primary site, its status (control), age, number of brain metastases, KPS and extra-cranial disease
  3. **: RPA was adjusted on centers, primary site and number of brain metastases
  4. ***: GPA was adjusted on centers, primary site and its status (control)
  5. ****: BSBM was adjusted on centers, primary site, its status (control), age and number of brain metastases
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Radiation Oncology

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