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Table 5 Criteria and radiation doses to the cochlea in correlation with the incidences of SNHL

From: Sensorineural hearing loss after concurrent chemoradiotherapy in nasopharyngeal cancer patients

Study RT Criteria Doses to cochlea Median follow up
& SNHL (per ear)
Kwong et al[10] Conv RT + chemo
(227 ears)
>15 dB at each frequency not defined 30 months
24.2%
Oh et al [19] Conv RT + chemo
(48 ears)
>15 dB at
4 kHz and PTA
mean inner ear dose 66.2 ± 6.2 1 year
29.2%
Ho et al [12] Conv RT + chemo
(526 ears)
>10 dB at
4 kHz and PTA
estimated
70-91 Gy, 2.5-3.5 Gy/F
4.5 years,
4 kHz 60%
PTA 18%
Chan et al [5] Conf RT vs
Conf RT + chemo
(170 ears)
>15 dB at
4 kHz
mean cochlea dose
33-71.7 Gy
24 months
33.3% vs 55%
(Conf RT vs
Conf RT+ chemo)
Chen et al.[4] Conf RT+ chemo
(44 ears)
>20 dB at one frequency
>10 dB at two frequencies
28.4 - 70.0 Gy 29 months
57%
Our study Conv RT +chemo
vs IMRT+ chemo
(134 ears, 68 patients)
>15 db loss at
4 kHz and PTA
Mean cochlea dose 25.09-75.54 Gy (IMRT) 14 months
4 kHz
Conv 48.75%
IMRT 37%
PTA Conv 5%
IMRT 7.4%
  1. Conv RT = Conventional radiation therapy Conf RT = Conformal radiation therapy