Table 5 Studies on spinal stereotactic re-irradiation (SBRT/SRS) after conventional radiotherapy
From: Spinal radiosurgery - efficacy and safety after prior conventional radiotherapy
Author | Gerszten et al. 2007 [16] | Sahgal et al. 2009 [30] | Choi et al. 2010 [31] | Garg et al. 2011 [25] |
|---|---|---|---|---|
No of patients | 344/500* | 39* | 42 | 59 |
No. of lesions | ≈344 | 37/60* | 51 | 63 |
Tumour volume (cc) | Â | Â | Â | Â |
Mean/median (range) | 46/29 (0.2-264) (n = 500*) | -/21 (0.4-177) (n = 37) | -/10.3 (0.2-128.6) | 67.1/51.2 (3.5-266) |
SRS/SBRT | 1 × 12.5-25 Gy (mean 20 Gy) | 8-30 Gy (median 24 Gy) | 10-30 Gy (median 20 Gy) | 5 × 6 Gy |
fractionation |  | 1-5 fractions (median 3) | 1-5 fractions (median 2) | 3 × 9 Gy |
Peripheral isodose | 80% | 60% | Â | 95% |
Follow up (months) | 21 (median) (n = 500*) | 7 (mean) | 7 (mean) | 17.6 (mean) |
Local control | Â | Â | Â | Â |
6 months | Â | Â | 87% | Â |
12 months | Â | 96% (n = 31) | 73% | 76% |
"long term" | 88% (n = 294*) | Â | Â | Â |
Overall survival | - | Â | Â | Â |
Median (months) | Â | 21 | Â | Â |
6 months | Â | Â | 81% | Â |
12 months | Â | Â | 68% | 76% |
24 months | Â | 45% | Â | Â |
Previous RT dose | 10 × 3 Gy or 14 × 2.5 Gy | Median 36 Gy 14 fractions | Median 40 Gy 2 Gy dose equivalent | < 45 Gy (subgroup analysis </>35 Gy) |