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Table 5 Studies on spinal stereotactic re-irradiation (SBRT/SRS) after conventional radiotherapy

From: Spinal radiosurgery - efficacy and safety after prior conventional radiotherapy

Author Gerszten et al. 2007 [16] Sahgal et al. 2009 [30] Choi et al. 2010 [31] Garg et al. 2011 [25]
No of patients 344/500* 39* 42 59
No. of lesions ≈344 37/60* 51 63
Tumour volume (cc)     
Mean/median (range) 46/29 (0.2-264)
(n = 500*)
-/21 (0.4-177)
(n = 37)
-/10.3 (0.2-128.6) 67.1/51.2 (3.5-266)
SRS/SBRT 1 × 12.5-25 Gy (mean 20 Gy) 8-30 Gy (median 24 Gy) 10-30 Gy (median 20 Gy) 5 × 6 Gy
fractionation   1-5 fractions (median 3) 1-5 fractions (median 2) 3 × 9 Gy
Peripheral isodose 80% 60%   95%
Follow up (months) 21 (median)
(n = 500*)
7 (mean) 7 (mean) 17.6 (mean)
Local control     
6 months    87%  
12 months   96% (n = 31) 73% 76%
"long term" 88% (n = 294*)    
Overall survival -    
Median (months)   21   
6 months    81%  
12 months    68% 76%
24 months   45%   
Previous RT dose 10 × 3 Gy or
14 × 2.5 Gy
Median 36 Gy
14 fractions
Median 40 Gy
2 Gy dose equivalent
< 45 Gy
(subgroup analysis
</>35 Gy)
  1. Abbreviations: SRS = radiosurgery; SBRT = Stereotactic body radiotherapy; *cohort included patients with/without pre-irradiation