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Table 3 OER variations with dose per fraction

From: Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications

 

Low LET (1 keV/μm)

High LET (100 keV/μm)

 

Dose (Gy)

OER

Dose (Gy)

OER

  

V79

T1

 

V79

T1

Baseline

2.0

2.16

2.74

1.0

1.70

1.66

Scenario 1

1.0

2.09 (-3%)

3.05 (+11%)

0.5

1.69 (-1%)

1.66 (0%)

(dose painting)

3.0

2.21 (+2%)

2.57 (-6%)

1.5

1.70 (0%)

1.66 (0%)

Scenario 2

0.5

2.05 (-5%)

3.32 (+21%)

0.25

1.69 (-1%)

1.66 (+0%)

(hyper-/hypo-fractionation)

20

2.52 (+17%)

2.14 (-22%)

10

1.77 (+4%)

1.68 (+1%)

  1. The calculations were performed for V79 and T1 cell lines irradiated at p h = 0.2 mmHg with various dose levels. OER values (with respect to p a = 30 mmHg) are given for the baseline as well as for two scenarios of dose painting and hyper- or hypofractionation, along with the relative differences to the baseline situation (in percent).