Table 1 Summary of results of recent series on fractionated radiotherapy for GH-secreting pituitary adenoma
Authors | type of | patients | total dose | follow-up | tumor control | biochemical remission |    late toxicity (%) | |
|---|---|---|---|---|---|---|---|---|
| Â | RT | Â | (Gy) | median (months) | % | % | visual | hypopituitarism |
Barkan et al., 1997 [8] | CRT | 38 | 46 | 80 | NA | 5 | NA | NA |
Thalassinos et al., 1998 [9] | CRT | 46 | 45-50 | 86 | 100 | 25 and 21 at 5 and 10 years | 0 | 30 at 10 years |
Barrande et al., 2000 [10] | CRT | 128 | 52 | 137 | NA | 35 and 53 at 5 and 10 years | 3 | 50 at 10 years |
Biermasz et al., 2000 [11] | CRT | 36 | 40 | 130 | NA | 40 and 61 at 5 and 10 years | 0 | 29 and 54 at 5 and 10 years |
Cozzi et al., 2001 [12] | CRT | 49 | 45 | 168 | 96 | 10 at 10 years | 4 | 12 |
Epaminonda et al., 2001 [13] | CRT | 67 | 40-75 | 120 | NA | 65 at 15 years | 0 | NA |
Jenkins et al., 2006 [15] | CRT | 656 | 45 | 84 | NA | 36 and 64 at 5 and 10 years | 0 | 58 at 10 years° |
| Â | Â | Â | Â | Â | Â | 74 at 15 years | Â | Â |
Minniti et al., 2005 [14] | CRT | 45 | 45 | 144 | 95 | 29 and 52 at 5 and 10 years | 0 | 45 at 10 years |
| Â | Â | Â | Â | Â | Â | 77 at 15 years | Â | Â |
Milker-Zabel et al.,2004 [26] | FSRT | 20 | 52.2 | 61 | 100 | 55 | 5 | 15 |
Colin et al., 2005 [27] | FSRT | 31* | 50.4 | 80 | 99 | 20 and 50 at 5 and 10 years | 0 | 37 |
Minniti et al., 2006 [28] | FSRT | 18* | 45 | 39 | 98 | 50 at 5 years* | 0 | 22 |
Roug et al., 2010 [29] | FSRT | 34 | 54 | 45 | 91 | 30 | NA | 29 |