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Table 2 Series evaluating radiation therapy or chemoradiotherapy of lung cancer in NSCLC with brain metastasis

From: Long-term survival in patients with non-small cell lung cancer and synchronous brain metastasis treated with whole-brain radiotherapy and thoracic chemoradiation

Study Year Number of patients Number of brain metastases Brain treatment Median survival, months 1-year survival rate (%) 2-year survival rate (%) 5-year survival rate (%) Prognostic factors
Chidel et al.[13] 1999 Sx = 2
Sx + RT = 3
RT = 8
Palliative = 15
1 Sx
WBRT
STS
and combination
Overall: 6.9
Definitive tx: 20.1
No definitive tx: 3.5
  12 (3-year)   WBRT
Aggressive thoracic treatment
Moazami et al.[31] 2002 Chemo/RT = 29
Sx = 59
42 pts: 1
49 pts: > 1
Metachronous brain lesions
Sx
WBRT
STS
and combinations
5.2 22 10 - Younger age
Stage IIIA
Lung resection
ECOG
No extracranial mets
Sx of brain mets
STS
Hu et al.[17] 2006 RT = 44
Chemo = 23
Chemo/RT = 13
1 Sx
STS
Overall: ~15
Stage I: 25.6
Stage II: 9.5
Stage III: 9.9
49.8 16.3 7.6 Thoracic stage I
Ampil et al.[26] 2007 > 65 year
RT = 22
No RT = 50
1 WBRT
STS
Sx
and combinations
RT = 5
No RT = 3
p = 0.28
RT = 14
No RT = 11
p= 0.28
- - Sx of brain mets
Flannery et al.[18] 2008 RT = 26
Chemo/RT = 9
Sx = 12
Preop Chemo + Sx = 5
1 STS Overall: 18
Definitive tx: 26.4
No definitive tx: 13.1
p < 0.0001
Overall: 71.3 Overall: 34.1 Overall: 21
RT: 34.6
No RT: 0
p < 0.0001
Definitive thoracic therapy
KPS
Louie et al.[16] 2009 Sx = 8
Chemo = 24
RT = 14
1 Sx + WBRT 7.8
Stage I/II: 14.7
Stage III: 7
- - - Lung surgerya
Primary lung treatmenta
> 8 weeks after brain Sxa
Stage I/II diseasea
Arrieta et al. (present series) 2010 Chemo-Chemo/RT = 30 > 1 WBRT 31.8 71.1 60.2   3-year OS for N0-1 was 60 vs. 24% for N2-3
  1. NSCLC: Non-small-cell lung cancer; Sx: Surgery; RT: Radiotherapy; WBRT: Whole-brain radiotherapy; STS: Stereotactic surgery; Comb: Combination; Mets: Metastasis/Metastases; Chemo: Chemotherapy; Chemo/RT: Chemo-radiotherapy; Preop: Pre-operative. a) Univariate analysis.