Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [18F]-fluoro-azomycinarabino-furanoside ([18F]FAZA)

Table 1 Tumor type and size-dependency of [¹⁸F]FAZA in CT26 colon carcinomas and PyV-mT mammary carcinomas

Tumor	Tumor size	1 h *p.i.*	2 h *p.i.*	3 h *p.i.*
PyV-mT (n = 20)	0.982 ± 0.958 cm³	1.31 ± 0.71	1.06 ± 0.69	0.92 ± 0.61
CT26 (n = 10)	0.279 ± 0.086 cm³	1.53 ± 0.43	1.14 ± 0.37	0.84 ± 0.26
PyV-mT (n = 12)	0.15 - 0.50 cm³	1.47 ± 0.89	1.13 ± 0.83	0.97 ± 0.70
PyV-mT (n = 4)	0.5 - 1.5 cm³	1.22 ± 0.59	1.05 ± 0.61	0.91 ± 0.56
PyV-mT (n = 4)	> 1.5 cm³	1.15 ± 0.41	0.86 ± 0.36	0.76 ± 0.42
CT26 (n = 4)	< 0.15 cm³	1.37 ± 0.41	0.92 ± 0.38	0.68 ± 0.38
CT26 (n = 6)	0.15 - 0.50 cm³	1.58 ± 0.45	1.22 ± 0.35	0.90 ± 0.22

Data are presented as %ID/cc ± SD. h: hour, p.i.: post injection. PyV-mT n = 9 mice, n = 20 tumors.

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