Skip to main content

Table 1 Albendazole arrests cell in the G2/M phase in a time and dose dependent fashion.

From: Albendazole sensitizes cancer cells to ionizing radiation

 

% G2/M cells

Time (hr)

ABZ (nM)

A2058

A375

H1530

H446

0

0

10.6

4.7

4.3

0.9

12

100

10.0

13.1

3.0

5.2

12

500

29.3

65.2

38.6

47.7

12

1000

32.3

87.1

46.3

71.4

  1. A2058 melanoma cells and H1530 SCLC cells were treated with ABZ concentrations ranging from 100 to 1000 nM for 12 hr, stained with propidium iodide, and analyzed for DNA content by flow cytometry. A total of 10 000 nuclei were analyzed from each sample, with the average of two replicates reported.