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Table 1 OAR dose constraints used for planning for the phase I trial

From: Dosimetric and motion analysis of margin-intensive therapy by stereotactic ablative radiotherapy for resectable pancreatic cancer

Critical Structure Dose Limits

Serial Tissue

Volume

Volume Max (Gy)

Max Point Dose (Gy)

Endpoint (≥ Grade 3)

Spinal Cord and medulla

< 0.35 cc

10 Gy

14 Gy

myelitis

 

< 1.2 cc

7 Gy

  

Spinal Cord Subvolume (5-6 mm above and below level treated)

< 10% of subvolume

10 Gy

14 Gy

myelitis

Skin

< 10 cc

23 Gy

26 Gy

ulceration

Stomach

< 10 cc

11.2 Gy

12.4 Gy

ulceration/fistula

Duodenum*

< 5 cc

< 10 cc

11.2 Gy

9 Gy

12.4 Gy

ulceration

Jejunum/Ileum*

< 5 cc

11.9 Gy

15.4 Gy

enteritis/obstruction

Colon*

< 20 cc

14.3 Gy

18.4 Gy

colitis/fistula

Liver

700 cc

9.1 Gy

 

Basic Liver Function

Renal cortex (Right & Left)

200 cc

8.4 Gy

 

Basic renal function