TY - JOUR AU - Rashid, Ayesha AU - Liu, Caiqiong AU - Sanli, Toran AU - Tsiani, Evangelia AU - Singh, Gurmit AU - Bristow, Robert G. AU - Dayes, Ian AU - Lukka, Himu AU - Wright, James AU - Tsakiridis, Theodoros PY - 2011 DA - 2011/10/26 TI - Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways JO - Radiation Oncology SP - 144 VL - 6 IS - 1 AB - Prostate cancer (PrCa) displays resistance to radiotherapy (RT) and requires radiotherapy dose escalation which is associated with greater toxicity. This highlights a need to develop radiation sensitizers to improve the efficacy of RT in PrCa. Ionizing radiation (IR) stimulates pathways of IR-resistance and survival mediated by the protein kinase Akt but it also activates the metabolic energy sensor and tumor suppressor AMP-Activated Protein Kinase (AMPK). Here, we examined the effects of the polyphenol resveratrol (RSV) on the IR-induced inhibition of cell survival, modulation of cell cycle and molecular responses in PrCa cells. SN - 1748-717X UR - https://doi.org/10.1186/1748-717X-6-144 DO - 10.1186/1748-717X-6-144 ID - Rashid2011 ER -