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Table 3 Actuarial survival rates related to +/- systemic therapy and tGTV volume

From: Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer

Parameters (n)

3y-OAS

3y-DFS

3y-DMFS

3y-LRC

entire cohort (112)

58%

50%

70%

61%

no systemic therapy (14)

25%

17%

50%

25%

any systemic therapy (98)

61%

53%

72%

64%

p-value

< 0.0001

0.01

0.1 (NS)

0.04

< 130 cc (91)

58%

51%

75%

62%

> 130 cc (21)

30%

38%

40%

40%

p-value

0.1 (NS)

0.2(NS)

0.001

0.05

no systemic therapy (14)

25%

17%

50%

25%

any systemic therapy, > 130 cc (19)

30%

40%

50%

45%

any systemic therapy, < 130 cc (79)

63%

55%

78%

76%

p-value

0.0001

0.03

0.01

0.04

  1. OAS: overall survival
  2. DMFS: distant metastasis free survival
  3. DFS: disease free survival
  4. LRC: loco-regional control