DNA double-strand break induction in Ku80-deficient CHO cells following Boron Neutron Capture Reaction

Radiation Oncology

Table 3 The average number of foci per cell and their RBE^a values in xrs-5 cells irradiated by the KUR thermal neutron beam.

Time after irradiation & Boron compound		BNCR				Gamma-ray
		Average number of γ-H2AX foci	RBE	Average number of 53BP1 foci	RBE	Average number of γ-H2AX foci	Average number of 53BP1 foci
30 min	BPA	24.8 ± 4.0	1.07	22.3 ± 4.1	1.16	23.1 ± 3.0	19.2 ± 2.0
	Boric Acid	26.0 ± 4.2	1.13	24.0 ± 4.0	1.25
60 min	BPA	22.6 ± 4.0*	1.86	20.4 ± 4.2*	1.73	12.1 ± 3.0	11.8 ± 2.0
	Boric Acid	24.7 ± 4.2*	2.04	22.8 ± 4.0*	1.93
90 min	BPA	18.4 ± 3.2*	1.67	19.4 ± 3.1*	1.90	11.0 ± 2.2	10.2 ± 1.2
	Boric Acid	20.2 ± 3.0*	1.84	21.6 ± 3.0*	2.12
120 min	BPA	15.6 ± 2.0*	1.73	15.5 ± 2.0*	1.76	9.0 ± 2.0	8.8 ± 1.0
	Boric Acid	15.2 ± 2.1*	1.69	16.6 ± 2.0*	1.89

^a RBE(relative biological effectiveness) was obtained by the ratio of average number of foci per cell compared to that of gamma rays.
* Significantly higher (p < 0.05) compared to gamma-ray irradiation

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