DNA double-strand break induction in Ku80-deficient CHO cells following Boron Neutron Capture Reaction

Radiation Oncology

Table 2 The average number of foci per cell and their RBE^a values in CHO-K1 cells irradiated by the KUR thermal neutron beam.

Time after irradiation & Boron compound		BNCR				Gamma-ray
		Average number of γ-H2AX foci/cell	RBE	Average number of 53BP1 foci/cell	RBE	Average number of γ-H2AX foci/cell	Average number of 53BP1 foci/cell
30 min	BPA	16.7 ± 4.2	0.85	15.6 ± 3.0	1.10	19.7 ± 3.0	14.2 ± 2.0
	Boric Acid	19.2 ± 4.0	0.97	16.8 ± 3.0	1.18
60 min	BPA	10.8 ± 4.0	1.26	8.8 ± 3.0	1.16	8.6 ± 3.0	7.6 ± 2.0
	Boric Acid	14.0 ± 4.2	1.63	10.4 ± 3.0	1.37
90 min	BPA	9.0 ± 3.2	1.50	8.0 ± 2.1*	2.67	6.0 ± 2.2	3.0 ± 1.2
	Boric Acid	11.0 ± 3.0	1.83	9.2 ± 3.0*	3.07
120 min	BPA	7.4 ± 3.0*	2.64	6.4 ± 1.0*	6.40	2.8 ± 2.0	1.0 ± 0.9
	Boric Acid	7.0 ± 3.2*	2.50	7.2 ± 1.1*	7.20

^a RBE(relative biological effectiveness) was obtained by the ratio of average number of foci per cell compared to that of gamma rays.
*Significantly higher (p < 0.05) compared to gamma-ray irradiation.

ISSN: 1748-717X