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Table 2 Acute toxicities occurring during preoperative chemoradiotherapy

From: Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study

  Patients, n (%)
Toxicity Grade 1 Grade 2 Grade 3 Grade 4
Haematological:     
   Leucocytopenia 12 (19.7) 5 (8.2) 3 (4.9) -
   Anaemia 5 (8.2) - - -
Non-haematological:     
   Diarrhoea 14 (22.9) 4 (6.5) 1 (1.6) -
   Fatigue 7 (11.5) 3 (4.9) - -
   Nausea 5 (8.2) - - -
   Anorexia 2 (3.3) - - -
   Dermatitis 3 (4.9) 14 (22.9) 6 (9.8) -
   Hand-food syndrome 5 (8.2) 2 (3.3) - -
   Cystitis 3 (4.9) - - -
   Hepatotoxicity 2 (3.3) 2 (3.3) - -
   Vascular - - 1 (1.6) 1 (1.6)
   Proteinuria 10 (16.4) 2 (3.3) 4 (6.5) -
   Hypertension 2 (3.3) 2 (3.3) 1 (1.6) -
   Infection 3 (4.9) 5 (8.2) - -
   Pain 20 (32.8) 3 (4.9) - -
   Bleeding 10 (16.4) - - -
  1. According to National Cancer Institute Common Toxicity Criteria (version 3)