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Table 2 Acute toxicities occurring during preoperative chemoradiotherapy

From: Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study

 

Patients, n (%)

Toxicity

Grade 1

Grade 2

Grade 3

Grade 4

Haematological:

    

   Leucocytopenia

12 (19.7)

5 (8.2)

3 (4.9)

-

   Anaemia

5 (8.2)

-

-

-

Non-haematological:

    

   Diarrhoea

14 (22.9)

4 (6.5)

1 (1.6)

-

   Fatigue

7 (11.5)

3 (4.9)

-

-

   Nausea

5 (8.2)

-

-

-

   Anorexia

2 (3.3)

-

-

-

   Dermatitis

3 (4.9)

14 (22.9)

6 (9.8)

-

   Hand-food syndrome

5 (8.2)

2 (3.3)

-

-

   Cystitis

3 (4.9)

-

-

-

   Hepatotoxicity

2 (3.3)

2 (3.3)

-

-

   Vascular

-

-

1 (1.6)

1 (1.6)

   Proteinuria

10 (16.4)

2 (3.3)

4 (6.5)

-

   Hypertension

2 (3.3)

2 (3.3)

1 (1.6)

-

   Infection

3 (4.9)

5 (8.2)

-

-

   Pain

20 (32.8)

3 (4.9)

-

-

   Bleeding

10 (16.4)

-

-

-

  1. According to National Cancer Institute Common Toxicity Criteria (version 3)
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Radiation Oncology

ISSN: 1748-717X

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