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Table 2 Univariate analysis of clinical variables for LMS and OS

From: Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma: A more accurate and appropriate assessment of prognosis

 

LMS

OS

Clinical Variable

HR

95%CI

P value *

HR

95%CI

P value *

Gender

1.084

0.739 to 1.591

0.681

1.645

0.726 to 1.563

0.747

Age

1.579

1.132 to 2.202

0.007

1.731

1.241 to 2.414

0.001

VCA-IgA (≤1:320 vs. >1:320)

1.595

1.067 to 2.383

0.022

1.358

0.909 to 2.028

0.135

EA-IgA (≤1:40 vs. >1:40)

1.038

0.687 to 1.566

0.861

1.153

0.762 to 1.743

0.501

AJCC T classification

1.316

0.939 to 1.845

0.110

1.610

1.139 to 2.276

0.007

AJCC N classification

1.355

0.972 to 1.889

0.073

1.469

1.050 to 2.056

0.024

Site of metastases 1

1.576

1.127 to 2.205

0.008

2.017

1.433 to 2.840

<0.001

Number of metastases 2

1.669

1.155 to 2.413

0.006

2.042

1.404 to 2.971

<0.001

Size of metastases 3 †

1.034

0.710 to 1.504

0.863

1.428

0.981 to 2.079

0.063

Mediastinal node metastases 4 ‡

1.061

0.753 to 1.496

0.735

1.234

0.875 to 1.740

0.230

Locoregional recurrence 5

1.277

0.787 to 2.071

0.323

1.058

0.650 to 1.719

0.822

Secondary metastases 6

3.100

2.116 to 4.541

<0.001

1.830

1.263 to 2.652

0.001

DFI (months, ≤24 vs. >24)

1.330

0.950 to 1.860

0.096

4.209

2.923 to 6.060

<0.001

  1. Abbreviation: LMS: lung metastasis survival; OS: overall survival; AJCC: American Joint Committee Cancer; DFI: disease-free interval; HR: hazard ratio; 95%CI: 95% confidence interval.
  2. 1 Unilateral vs. Bilateral; 2 Solitary vs. Multiple; 3 ≤ 3 cm vs. > 3 cm; 4 Absent vs. Present; 5 Absent vs. Present; 6 Absent vs. Present.
  3. † A mass in diameter.
  4. ‡ Size in the short-axis diameter.
  5. * Cox proportional hazards regression models.