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Table 3 Target volume coverage and homogeneity indices for selected challenging cases

From: Helical tomotherapy in the treatment of pediatric malignancies: a preliminary report of feasibility and acute toxicity

Tumor site

Histology

(number of cases)

Target volume

Prescribed dose, Gy

Mean PTV dose, Gy*

Coverage Index§

Homogeneity Index§

Irradiation time (sec) †

CNS (craniospinal irradiation)

Medulloblastoma (16)

Whole brain

23,4

23,98 ± 0,17

0,78 (0,53-0,95)

1,10 (1,07-1,21)

912,7

(367,4 - 1991,2)

   

36,0

36,96 ± 0,15

0,74 (0,47-0,90)

1,10 (1,08-1,12)

 
  

Cribriform plate

23,4

23,88 ± 0,07

0,86 (0,75-0,95)

1,07 (1,04-1,09)

 
   

36,0

36,86 ± 0,30

0,79 (0,62-1,00)

1,07 (1,06-1,09)

 
  

Spinal canal

23,4

23,90 ± 0,16

0,87 (0,73-0,91)

1,07 (1,06-1,09)

 
   

36,0

36,82 ± 0,45

0,90 (0,78-1,00)

1,07 (1,06-1,13)

 
  

Tumor bed

54,0

55,06 ± 0,49

0,81 (0,57-0,98)

1,05 (1,02-1,13)

 

CNS

Glioma (7)

Tumor/tumor bed

45,0-59,4

45,18-60,76

0,89 (0,81-0,98)

1,04 (1,02-1,06)

328,0

(211,8 - 957,0)

Abdomen

Neuroblastoma (7)

Tumor bed

21,0

21,34 ± 0,13

0,85 (0,48-0,94)

1,07 (1,03-1,08)

256,8

(158,8 - 293,2)

Thorax

Rhabdomyosarcoma (1)

Right pleura

50,4

50,11 ± 0,98

0,84

1,02

730,3

 

PNET (Askin's tumor) (1)

Hemithorax

14,40

14,83 ± 0,19

0,89

1,09

554,1

  

GTV

48,60

49,87 ± 0,79

0,74

1,06

 
 

Ewing sarcoma (1)

Hemithorax

14,00

14,38 ± 0,24

0,77

1,07

519,0

  

Tumor

48,00

49,29 ± 0,22

0,90

1,08

 
  

Met L2-S1

48,00

49,22 ± 0,15

0,92

1,05

 

Pelvis

Rhabdomyosarcoma (1)

Inguinal nodes

41,40

41,94 ± 0,59

0,91

1,05

327,2

  

Tumor bed

50,40

51,10 ± 0,62

0,65

1,04

 

Total lymphatic irradiation

Hodgkin lymphoma (1)

Liver, spleen, total lymphatic

12,00

12,46 ± 0,25

0,76

1,07

538,2

  

Total lymphatic

21,00

21,74 ± 0,22

0,74

1,09

 

Orbit

PNET (1)

Tumor

48,60

49,40 ± 0,86

0,55

1,05

344,1

 

Rhabdomyosarcoma (1)

Tumor bed

50,40

51,93 ± 0,83

0,94

1,07

479,8

 

Melanoma (1)

Tumor bed

50,40

51,16 ± 0,42

0,98

1,08

329,6

  1. * Data are presented as mean ± SD or as a range of mean PTV dose
  2. § Data are presented as median (range) for groups and as single values for individual cases
  3. † Data are presented as irradiation time for the phase of treatment with longest irradiation time and as median (range) for groups