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Figure 4 | Radiation Oncology

Figure 4

From: Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines

Figure 4

Effect of Loratadine and Radiation on DNA Damage. HT29 cells were either treated with loratadine (75 μM, 24 hrs) prior to exposure to 8 Gy radiation, or treated with loratadine or radiation alone. Cells were analyzed by pulsed-field gel electrophoresis at 0, 3, 6, and 24 hrs. (A) Radiation-induced DNA fragments were evident immediately following irradiation and resolved by 24 hrs. Loratadine-treated irradiated cells demonstrated increased and persistent DNA fragmentation and an additional band corresponding to smaller DNA fragments (arrows). (B) Densitometry analysis confirmed increased DNA fragments in irradiated and loratadine-treated cells. (C) Loratadine alone induced DNA fragmentation and an additional band corresponding to smaller DNA fragments (arrow). The graph represents the densitometric value of the sample for a single representative experiment, LR = loratadine-treated.

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Radiation Oncology

ISSN: 1748-717X

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