Skip to main content
Figure 3 | Radiation Oncology

Figure 3

From: Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines

Figure 3

Effect of Loratadine and Radiation on DNA Repair Proteins. HT29 cells were either treated with loratadine (75 μM, 24 hrs) prior to exposure to 8 Gy radiation, or treated with loratadine or radiation alone. γH2AX expression, determined by western blot at 1, 6, and 24 hrs after irradiation, increased within 1 hr after irradiation and returned to baseline by 24 hrs. Loratadine treatment enhanced this expression at 1 hr and resulted in persistent expression at 24 hrs. Loratadine alone also increased γH2AX expression with maximal expression at 6 hrs. The graph represents the ratio of the densitometric value of the sample compared to control for a single representative experiment, LR = loratadine-treated.

Back to article page