Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence

Radiation Oncology

Table 4 The 3-year clinical outcomes according to prognostic factors.

Factor	Overall survival (%)	p	Disease-specific survival (%)	p	Disease-free survival (%)	p	Locoregional control (%)	p	Distant metastasis-free survival (%)	p
Age
≤50/>50	78/85	0.61	78/89	0.24	66/72	0.59	72/74	0.97	93/98	0.18
Gender
Male/Female	84/51	0.1	86/60	0.32	71/42	0.51	74/56	0.9	97/80	0.14
pT
pT1-2/pT3-4	87/75	0.08	89/79	0.15	72/66	0.65	73/73	0.88	98/92	0.13
pN
pN0/pN1-3	96/33*	a	98/34*	a	81/32*	a	81/46*	a	100/79*	A
Pathology stage
I-II/III-IV	98/66*	a	100/69*	a	81/58*	0.01	81/65	0.07	100/92*	0.04
Grade
1/2+3	83/81	0.99	100/83	0.35	100/67	0.17	100/71	0.2	100/96	0.63
Surgical margin
(+)/(-)	63/83	0.26	63/86	0.16	44/71	0.21	44/75	0.12	100/96	0.63
≤2/>2 (mm)	64/94*	0.02	66/97*	0.01	59/93*	b	64/97*	b	91/97	0.37
≤3/>3 (mm)	70/91	0.18	71/95	0.09	67/91	0.06	71/95*	0.04	93/95	0.74
ECS
(+)/(-)	25/77*	a	33/77*	b	50/71*	0.01	75/73	0.62	75/76	0.02
PNI
(+)/(-)	72/85	0.23	72/80	0.15	64/71	0.32	73/73	0.64	91/96	0.41
Bone invasion
(+)/(-)	85/91	0.2	85/91	0.2	55/70	0.46	55/74	0.3	100/98	0.63
Skin invasion
(+)/(-)	76/94	0.19	82/94	0.48	56/64	0.78	67/64	0.27	84/100	0.05

*, Statistically significant difference; a, p < 0.001; b, p < 0.01; PNI, perineural invasion; ECS, extracapsular spread; (+), positive; (-), negative.

ISSN: 1748-717X