Figure 4
From: Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo
Overall tumor response, expressed as modal specific growth delay in days, derived from figure 3 plotted against total-cell-killing derived from figure 1. Each cell line is represented by four responses shown as two responses to fractionated doses (8 × 2 Gy and 2 × 5Gy) connected by dotted lines and two responses to single acute fractions (1 × 7.5 Gy and 1 × 15.0 Gy) connected by solid lines. Data in the left hand panel shows responses of the S-R cells fall into a common linear pattern with a correlation coefficient of R2 = 0.7271. The data in the right hand show four lines response in a relatively linear pattern (R2 = 0.7271) but the cell lines in the right hand panel do not The best fit correlation line for the data in the left hand panel is shown as a solid line on that panel and also redrawn on the right hand panel for comparison. The trapezoid in the right hand panel includes all data from the left hand panel, emphasizing the differences in scale between the two panels. Data points are individual measurements.