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Figure 5 | Radiation Oncology

Figure 5

From: Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo

Figure 5

The effects of anti-DPK3-scFv on DNA double-strand breaks repair. (A) The comet images detected by neutral single-cell gel electrophoresis (SCGE). (B) DNA DSB and repair expressed as the comet tail moment of SCGE assays in HeLa, HeLa-pcDNA and HeLa-DPK3-scFv cells at given times post-4 Gy irradiation. The data are means and standard deviation from three independent experiments. * P < 0.05 as compared with parental HeLa cells and control cells at the same time point. (C) Immunofluorescence detection of γ-H2AX foci in the cells 0.5 h to 4 h post-irradiation. (D) The residual number of γ-H2AX foci per nucleus in the cells 0.5 h to 4 h post-irradiation. * P < 0.05 as compared with parental HeLa cells and control cells at the same time point.

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