Table 3 Selected studies for locally advanced pancreatic cancer employing chemoradiation ± chemotherapy

Johnson[59]

(129)

Lithium Gamonelate

-

5.4

n.a.

Maisey[56]

(44/46)

5/FU PVI

5-FU/MMC

-

32% 1 year

43% 1 year

n.a.

Louvet[60]

(47/50)

Gem

Gem/Ox

-

-^$

10.3

10.3

p = n.s.

Rocha Lima[61]

(24/27)

Gem

Gem/Iri

-

-^$

11.7

9.8

p = n.s.

Van Cutsem[62]

(80/82)

Gem

Gem/tipifarnib

-

8.7

11

p = n.s.

GITSG 1985[77]

(25/83/86)

-

5-FU

5-FU

60

40

60

5.2

9.6

9.2

p < 0.01

GITSG 1988[50]

(24/24)

SMF

SMF

54

-

6.5

5.1

p < 0.02

Klaassen[52]

(44/47)

5-FU

5-FU

40

-

8.3

8.2

n.a.

Chauffert[53]

(59/60)

5-FU(PVI)/Cis+Gem

Gem

60

-

8.0

14.5

p = 0.03

Loehrer[55]

(36/38)

Gem+ Gem

Gem

50.4

-

11.0

9.2

p = 0.034

Crane[66]

(53/61)

Gem

5-FU(PVI)

30 (10#)

11

9

p = n.s.

Li[78]

(18/16)

Gem

5-FU

50.4

14.5

6.7

p = 0.027

Ishii[63]

(20)

5-FU(PVI)

50.4

10.3

n.a.

McGinn[65]

(37)

Gem

24-42

11.6

n.a.

Shinchi[47]

(16/15)

5-FU(PVI)

Supportive care

50.4

-

13.2

6.4

n.a.

Brunner[67]

(40/42)

Gem/Cis+ Gem

Gem/Cis

55.8

55.8

13 8

p < 0.0001

Huguet[24]

(72/56)

5-FU(PVI)+ as below

FolFuGem, GemOx

55

-

15

11.7

p = 0.0009

Kachnic[64]

(23)

5-FU+ Gem

50.4

13

n.a.