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Figure 3 | Radiation Oncology

Figure 3

From: Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus

Figure 3

Volume densities of activated microglia measured within the SGZ and GCL at 12 weeks post-irradiation. A. Relative to CTL-SHAM, CD68+ activated microglia in the SGZ are significantly (p < 0.001) and dose-dependently increased following 10 Gy- and 15 Gy-WBI. B. CD68+ activated microglia are unaffected by ramipril in either the Control group (CTL-SHAM vs. CTL-AVS) or in the 10 Gy-WBR group (10 Gy vs. 10 Gy-AVS). Thus, the mitigating effects of ramipril on granule cell progenitor proliferation and neurogenesis following 10 Gy-WBI are not accompanied by a decrease in activated microglia. Error bars represent the standard error of the mean for each treatment group.

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