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Figure 2 | Radiation Oncology

Figure 2

From: Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus

Figure 2

Linear densities of Ki-67+ progenitors and DCX+ immature neurons within the SGZ at 12 weeks post-irradiation. A. Relative to CTL-SHAM, Ki-67+ progenitor proliferation is significantly (p < 0.001) reduced following 10 Gy- and 15 Gy-WBI. Ramipril mitigates the reduction in Ki-67+ progenitors following 10 Gy-WBI (p < 0.05), but not following 15 Gy-WBI. B. Relative to CTL-SHAM, DCX+ immature granule cell neurons are significantly (p < 0.001) and dose-dependently (p < 0.01) reduced following 10 Gy- and 15 Gy-WBI. Ramipril mitigates the reduction in neurogenesis following 10 Gy-WBI (p < 0.05), but not following 15 Gy-WBI. Error bars represent the standard error of the mean for each treatment group. (* = p < 0.05; ** = p < 0.01).

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