From: Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors?
Author | Recipe | Biological model | Purpose |
---|---|---|---|
Haken et al. 1997 | 0A | NTCP (Lyman model) TD50 = 45 Gy, m = 0.15, m = 0.69; TCP (Simple logistic function) D50 = 60 Gy, k = 4; | To investigate potential benefits of eliminating motion margin through liver tumor treated with conformal therapy |
McKenzie et al. 2000 | A | No | How should motion margin be combined with other margins around CTV |
Van Herk et al. 2003 | 0.7A |
α/β = 1~10 | To investigate biologic and physical fractionation effects of random geometric errors and respiration motion with Gaussian blurring of the plan dose |
Molinelli et al. 2008 | 0 5 mm 10 mm | EUD(SF2 = 0.5) gEUD(a = -20) | To quantify the potential benefits of CTV-to-PTV margin reduction for SBRT of liver tumor |
This study | 1A 0.7A 0A |
Dref = 2 Gy; SF2 = 0.3, 0.5,0.7 | To investigate adequate margin for different clinical stage of liver tumor treated with fractionation IMRT |