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Table 1 Summary of motion margin recipes and the study designs.

From: Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors?

Author

Recipe

Biological model

Purpose

Haken et al. 1997

0A

NTCP (Lyman model)

TD50 = 45 Gy, m = 0.15, m = 0.69;

TCP (Simple logistic function)

D50 = 60 Gy, k = 4;

To investigate potential benefits of eliminating motion margin through liver tumor treated with conformal therapy

McKenzie et al. 2000

A

No

How should motion margin be combined with other margins around CTV

Van Herk et al. 2003

0.7A

α/β = 1~10

To investigate biologic and physical fractionation effects of random geometric errors and respiration motion with Gaussian blurring of the plan dose

Molinelli et al. 2008

0

5 mm

10 mm

EUD(SF2 = 0.5)

gEUD(a = -20)

To quantify the potential benefits of CTV-to-PTV margin reduction for SBRT of liver tumor

This study

1A

0.7A

0A

Dref = 2 Gy; SF2 = 0.3, 0.5,0.7

To investigate adequate margin for different clinical stage of liver tumor treated with fractionation IMRT