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Table 1 The extent of the irradiation effects ("cumulative pseudolesion" in cm3) and calculated D90 (for α/β = 2 Gy) with respect to the minimal prescribed dose inside of the clinical target volume (CTV) in the different irradiation sessions.

From: Radiobiological restrictions and tolerance doses of repeated single-fraction hdr-irradiation of intersecting small liver volumes for recurrent hepatic metastases

Pat.

D90 (2 Gy)

Cum. Pseudo-lesion Volume (cm3)

Fractions (n)

Interval between inter-ventions (months)

Interval between first irradiation & last MRI (months)

Interval between last irradiation & last MRI (months)

Minimal prescribed dose inside CTV (Gy)

Liver Volume (cm3)

1

18.80

289

3

3/3

17

11

20/20/20

1960

2

16.20

327

2

7

14

7

25/15

2184

3

35.20

135

4

7/1/8

31

3

15/20/20/20

1123

4

25.30

172

3

4/3

18

11

20/20/15

1548

5

17.20

710

2

12

5

4

15/15

2077

6

25.15

381

2

13

13

12

15/20

1357

7

16.40

239

2

7

18

11

25/15

1847

8

14.35

803

2

6

13

7

15/20

1463

9

31.90

92

4

4/4/8

24

7

15/15/20/20

1424

10

23.65

425

2

14

18

4

20/15

2054

11

28.35

178

2

5

10

4

15/20

1662

12

21.64

668

3

4/6

16

6

20/15/20

2165

13

21.70

207

2

10

12

3

15/15

1439

14

15.90

529

3

1/5

9

4

15/15/15

1441

15

16.30

238

2

11

14

3

20/15

2025

16

21.75

244

3

1/7

10

3

20/20/15

1604

17

33.20

476

4

1/10/1

19

9

25/15/25/25

1951

18

20.55

227

2

1

5

4

20/20

1387

19

14.90

319

2

11

10

8

15/15

1428

20

29.60

75

2

9

12

3

20/20

1246

Mean

22.40

336.7

3

5

14

6

20

1669.16

  1. The different time intervals between the interventions and the different time intervals between the interventions and acquisition of MRI examinations are shown.