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Table 1 The extent of the irradiation effects ("cumulative pseudolesion" in cm3) and calculated D90 (for α/β = 2 Gy) with respect to the minimal prescribed dose inside of the clinical target volume (CTV) in the different irradiation sessions.

From: Radiobiological restrictions and tolerance doses of repeated single-fraction hdr-irradiation of intersecting small liver volumes for recurrent hepatic metastases

Pat. D90 (2 Gy) Cum. Pseudo-lesion Volume (cm3) Fractions (n) Interval between inter-ventions (months) Interval between first irradiation & last MRI (months) Interval between last irradiation & last MRI (months) Minimal prescribed dose inside CTV (Gy) Liver Volume (cm3)
1 18.80 289 3 3/3 17 11 20/20/20 1960
2 16.20 327 2 7 14 7 25/15 2184
3 35.20 135 4 7/1/8 31 3 15/20/20/20 1123
4 25.30 172 3 4/3 18 11 20/20/15 1548
5 17.20 710 2 12 5 4 15/15 2077
6 25.15 381 2 13 13 12 15/20 1357
7 16.40 239 2 7 18 11 25/15 1847
8 14.35 803 2 6 13 7 15/20 1463
9 31.90 92 4 4/4/8 24 7 15/15/20/20 1424
10 23.65 425 2 14 18 4 20/15 2054
11 28.35 178 2 5 10 4 15/20 1662
12 21.64 668 3 4/6 16 6 20/15/20 2165
13 21.70 207 2 10 12 3 15/15 1439
14 15.90 529 3 1/5 9 4 15/15/15 1441
15 16.30 238 2 11 14 3 20/15 2025
16 21.75 244 3 1/7 10 3 20/20/15 1604
17 33.20 476 4 1/10/1 19 9 25/15/25/25 1951
18 20.55 227 2 1 5 4 20/20 1387
19 14.90 319 2 11 10 8 15/15 1428
20 29.60 75 2 9 12 3 20/20 1246
Mean 22.40 336.7 3 5 14 6 20 1669.16
  1. The different time intervals between the interventions and the different time intervals between the interventions and acquisition of MRI examinations are shown.