Chemo-radiation with or without mandatory split in anal carcinoma: experiences of two institutions and review of the literature

Table 4 Review of the literature: trials using IMRT.

study	n	Stage	Technique	total	RT dose (Gy) pelvic	inguinal	Split	CT	OS (%)	LC (%)	CFS (%)	skin	diarrhea	BM	adherence (%)
Vuong (ASCO 2008)	26		IMRT	54-59.4	30	30	cont	MMC, 5-FU		71 (1 y)		23	4	42	76
McGill	40		3d-CRT	54-59.4	30	30	cont	MMC, 5-FU		85 (1 y)		19	3	18	93
Salama (2007)	53²	T1-4N0-3	IMRT	51,5	45	45	cont	MMC, 5-FU	93 (18 mo)	84 (18 mo)	84 (18 mo)	38	15		58¹
Chicago
Milano (2005)	17	T2-4N0-3	IMRT	54-59.4	45	45	cont	MMC, 5-FU	91 (2 y)		82 (2 y)	0	0	53	100
Chicago

IMRT = intensity-modulated radiotherapy, EBRT = external beam radiotherapy, RT = radiotherapy, CT = chemotherapy, T = tumor stage, N = nodal stage, w = week, mo = months, y = years, OS = overall survival, LC = local control, CFS = colostomy-free survival, cont = continuous, e = elective, 1 = median 4 d interruption, 2 = 15% HIV-positive. References: Vuong [22], Salama [33], Milano [34]

ISSN: 1748-717X