study | n | Stage | total | RT dose (Gy) pelvic | inguinal | Split | CT | OS (%) | LC (%) | CFS (%) | toxicity overall | skin | diarrhea | BM | adherence (%) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
prospective, randomized | |||||||||||||||
Ajani (2008) | 324 | T2-4 | 55-59 | 45 | 45 | cont | MMC, 5-FU | 75 (5 y) | 87 (5 y)1 | 90 (5 y) | 87 | 48 | 23 | 61 | |
RTOG 98-11 | 320 | T2-4 | 55-59 | 45 | 45 | cont | Cispl., 5-FU | 70 (5 y) | 81 (5 y)1 | 81 (5 y) | 83 | 41 | 24 | 42 | |
Flam (1996) | 146 | T1-4N0-3 | 45-50.4 | 30,6 | 30.6-45 | split (4 w) | MMC, 5-FU | 74 (4 y) | 84 (4 y) | 71 (4 y) | 262 | 73 | 18 | ||
RTOG 87-04/ECOG 1289 | (59.4*) | (54*) | |||||||||||||
UKCCR (1997) | 283 | >T1N0 | 604 | 45 | e (45) | split (6 w) | MMC, 5-FU | 65 (3 y) | 61 (3 y) | 27 | 17 | 5 | 4 | ||
Bartelink (1997) | 52 | T3-4N0-3 | 60 - 65 | 45 | e (60-65) | split (6 w) | MMC, 5-FU | 65 (5 y) | 69* (5 y) | 71 (5 y) | 56 | 19 | |||
EORTC | T1-2N1-3 | ||||||||||||||
prospective, non-randomized | |||||||||||||||
John (1996), Konsky (2008) | 20 | T1-4N0-3 | 59,6 | 30.6 - 455 | 30.6-45 | cont | MMC, 5-FU | 85 (5 y) | 90 (5 y) | 75 (5 y) | 80 | ||||
RTOG 92-08 | 46 | T1-4N0-3 | 59,6 | 30.6 - 455 | 30.6-45 | split (2 w) | MMC, 5-FU | 67 (5 y) | 73 (5 y) | 58 (5 y) | 63 | 32 | 9 | 40* | 87 |
Cummings (1991) | 192 | T1-4N0-3 | 506 | 50 | 50 | cont | MMC, 5-FU | 75 | 88 | 75 | |||||
PMH | T1-4N0-3 | 506 | 50 | 50 | split | MMC, 5-FU | 65 | 93 | 50 | ||||||
T1-4N0-3 | 48 | 48 | 48 | split | MMC, 5-FU | 65 | 85 | 36 | |||||||
Bosset (2003) | 43 | T2-4N0-3 | 59,4 | 36 | e (36) | split (2 w) | MMC, 5-FU | 81 (3 y) | 88 (3 y) | 81 (3 y) | 28 | 12 | 2 | 93 | |
EORTC | (>4 cm) | ||||||||||||||
Vuong (2003) | 30 | T2-4N0-3 | 54 | 27-30 | 27 | cont | MMC, 5-FU | 64 (4 y) | 91 (4 y) | 20 | 3 | 13 | 100 | ||
McGill | |||||||||||||||
Schneider (1992) | 46 | T0-4N0-3 | 50 (56-68)7 | 50 | 50 | cont | MMC, 5-FU | 84 (5 y) | 83 (5 y) | 80 (5 y) | 35 | 24 | 28-35 | ||
Erlangen | |||||||||||||||
Sischy (1989) | 79 | T1-4N0-3 | 40,8 | 40,8 | 40,8 | cont | MMC, 5-FU | 73 (3 y) | 71 (3 y)8 | 19 | 1 | 3 | 51 | ||
RTOG |