Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy

Table 3 Multivariate analysis of the dosimetric and clinical factors associated with SARP for 94 patients

Varibale	OR	95%CI	p value*
NTCP	10.411	1.835-56.024	0.008
MLD	3.199	0.196-52.380	0.415
V5	4.024	0.765-21.163	0.100
V10	9.023	1.910-42.625	0.005
V15	4.024	0.765-21.163	0.100
V20	2.801	0.834-9.403	0.096
V25	3.423	0.713-16.421	0.124
V30	2.613	0.759-8.995	0.128
V35	2.313	0.751-7.122	0.144
V40	2.485	0.292-21.152	0.405
V45	1.219	0.373-14.146	0.475
V50	1.613	0.229-22.824	0.318
V55	1.446	0.215-20.061	0.594
V60	1.139	0.070-18.612	0.527
COPD	0.154	0.008-3.159	0.225
FEV1	0.119	0.010-1.346	0.085

Abbreviation: MLD = mean lung dose; NTCP = normal tissue complication probability; SARP = severe acute radiation pneumonitis; * Univariate logistic regression analysis; COPD = chronic obstructive pulmonary disease; FEV1 = forced expiratory volume in 1 second; OR = the value of odds ratio; 95%CI = confidence interval

ISSN: 1748-717X