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Table 2 Univariate analysis of the dosimetric parameters(MLD, NTCP, V5-V60) for predicting development of SARP for 94 patients

From: Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy

Variable

Median(range)

No RP(n = 83)

RP(n = 11)

pvalue*

MLD

11.59(6.53-18.11) Gy

= 11.26, SD = 2.81

= 14.91, SD = 2.91

0.001

NTCP

2.33% (0.51-9.68%)

= 2.51, SD = 1.73

= 5.94, SD = 2.40

0.001

V5

58.73% (32.89-97.65%)

= 58.43, SD = 16.57

= 69.23, SD = 12.47

0.006

V10

42.16%(25.28-83.34%)

= 41.13, SD = 12.69

= 52.42, SD = 11.05

0.001

V15

29.53%(16.46-58.51%)

= 28.94, SD = 9.12

= 38.30, SD = 7.65

0.005

V20

18.15% (9.46-31.08%)

= 18.59, SD = 6.03

= 28.02, SD = 7.09

0.002

V25

12.96% (5.90-26.26%)

= 12.88, SD = 4.42

= 20.91, SD = 6.98

0.001

V30

10.00% (4.68-21.43%)

= 9.72, SD = 3.45

= 15.69, SD = 6.00

0.008

V35

9.92% (3.89-18.65%)

= 7.57, SD = 2.86

= 11.95, SD = 4.64

0.011

V40

8.20% (3.29-13.61%)

= 5.91, SD = 2.48

= 9.26, SD = 3.75

0.015

V45

7.42% (2.73-10.99%)

= 4.41, SD = 2.25

= 6.54, SD = 3.47

0.007

V50

7.07%(1.94-8.82%)

= 3.15, SD = 1.94

= 4.89, SD = 2.15

0.007

V55

6.75% (1.33-6.32%)

= 2.03, SD = 1.65

= 3.19, SD = 1.75

0.033

V60

5.76% (0.80-4.20%)

= 1.23, SD = 1.09

= 1.66, SD = 1.15

0.039

  1. Abbreviation: MLD = mean lung dose; NTCP = normal tissue complication probability; SARP = severe acute radiation pneumonitis; * Comparison of dosimetric factors between patients who developed severe acute RP and those who did not