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Table 4 Risk factors of severe RP

From: Prescreening based on the presence of CT-scan abnormalities and biomarkers (KL-6 and SP-D) may reduce severe radiation pneumonitis after stereotactic radiotherapy

  Patients with G4-5 RP Patients without G4-5 RP p value
Total 9 (8%) 108 (92%)  
Patient specific factors    
   Pulmonary function    
VC (L)    
mean +/- SD 3.27 +/- 0.65 2.75 +/- 0.85 N.S.
range 2.76-4.01 1.54-4.07  
FEV 1.0 (L)    
mean +/- SD 2.11 +/- 0.68 1.87 +/- 0.82 N.S.
range 1.59-3.24 0.59-3.24  
   K-PS (%)    
90 5 (56%) 52 (48%) N.S.
80 4 (44%) 56 (52%)  
   Age (y)    
mean +/- SD 73.3 +/- 6.8 70.1 +/- 14.1 N.S.
range 68-80 24-93  
   COPD    
With 2 (22%) 22 (20%) N.S.
Without 8 (78%) 86 (80%)  
Treatment specific factors    
   Size of the PTV (cc)    
mean +/- SD 29.4 +/- 33.2 42.5 +/- 13.7 N.S.
range 7.7-120.9 7.5-239.4  
   Mean lung dose (Gy)    
mean +/- SD 5.0 +/- 2.3 4.2 +/- 1.4 N.S.
range 2.7-9.4 1.7-7.9  
   Lung V20 (%)    
mean +/- SD 5.9 +/- 2.7 5.8 +/- 2.6 N.S.
range 2.6-11.2 1.0-11.0  
   Target location    
Central 2 (22%) 17 (16%) N.S.
Peripheral 7 (78%) 91 (84%)  
  1. Abbreviation:
  2. COPD = chronic obstructive pulmonary diseases
  3. RP = radiation pneumonitis
  4. G4-5 = grades 4-5
  5. PTV = planning target vlume
  6. FEV = Forced expiratory volume
  7. K-PS = Karnofsky Performance status
  8. N.S. = not significant