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Table 4 Risk factors of severe RP

From: Prescreening based on the presence of CT-scan abnormalities and biomarkers (KL-6 and SP-D) may reduce severe radiation pneumonitis after stereotactic radiotherapy

 

Patients with G4-5 RP

Patients without G4-5 RP

p value

Total

9 (8%)

108 (92%)

 

Patient specific factors

   

   Pulmonary function

   

VC (L)

   

mean +/- SD

3.27 +/- 0.65

2.75 +/- 0.85

N.S.

range

2.76-4.01

1.54-4.07

 

FEV 1.0 (L)

   

mean +/- SD

2.11 +/- 0.68

1.87 +/- 0.82

N.S.

range

1.59-3.24

0.59-3.24

 

   K-PS (%)

   

90

5 (56%)

52 (48%)

N.S.

80

4 (44%)

56 (52%)

 

   Age (y)

   

mean +/- SD

73.3 +/- 6.8

70.1 +/- 14.1

N.S.

range

68-80

24-93

 

   COPD

   

With

2 (22%)

22 (20%)

N.S.

Without

8 (78%)

86 (80%)

 

Treatment specific factors

   

   Size of the PTV (cc)

   

mean +/- SD

29.4 +/- 33.2

42.5 +/- 13.7

N.S.

range

7.7-120.9

7.5-239.4

 

   Mean lung dose (Gy)

   

mean +/- SD

5.0 +/- 2.3

4.2 +/- 1.4

N.S.

range

2.7-9.4

1.7-7.9

 

   Lung V20 (%)

   

mean +/- SD

5.9 +/- 2.7

5.8 +/- 2.6

N.S.

range

2.6-11.2

1.0-11.0

 

   Target location

   

Central

2 (22%)

17 (16%)

N.S.

Peripheral

7 (78%)

91 (84%)

 
  1. Abbreviation:
  2. COPD = chronic obstructive pulmonary diseases
  3. RP = radiation pneumonitis
  4. G4-5 = grades 4-5
  5. PTV = planning target vlume
  6. FEV = Forced expiratory volume
  7. K-PS = Karnofsky Performance status
  8. N.S. = not significant
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Radiation Oncology

ISSN: 1748-717X

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