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Table 1 Results of the ANOVA analysis

From: Safety margin in irradiation of colorectal liver metastases: assessment of the control dose of micrometastases

Distance of the local recurrence to the former tumor margin
(mm)
Maximum upper 97.5% tolerance limit with coverage of 87.5%
(Gy)
Maximum upper 97.5% tolerance limit with coverage of 75%
(Gy)
1 18.66 17.56
2 18.49 17.40
3 18.32 17.23
4 18.16 17.06
5 17.99 16.90
6 17.82 16.73
7 17.66 16.57
8 17.49 16.41
9 17.33 16.24
10 17.17 16.08
11 17.01 15.92
12 16.85 15.76
13 16.69 15.59
14 16.53 15.43
15 16.37 15.27
16 16.22 15.11
17 16.06 14.96
18 15.90 14.80
19 15.75 14.64
20 15.60 14.48
21 15.45 14.33
22 15.30 14.17
23 15.15 14.01
  1. Maximum upper 97.5% tolerance limits with coverage of 87.5% and 75%. 87.5% means that 87.5% of the data (dose measured in the center of the micrometastasis) are below the upper limit of the tolerance interval (with a confidence of 97.5%).
  2. The Maximum upper 97.5% tolerance limit with coverage of 87.5% for the distance of 21 mm was 15.4 Gy: 87.5% of the doses in the isocenters of the micrometastases with a distance of < 21 mm to the initial tumor margin were less than 15.4 Gy. Thus < 15.4 Gy at a distance of < 21 mm was insufficient to avoid tumor growth from micrometastases in 87.5% of the cases.