Choline PET based dose-painting in prostate cancer - Modelling of dose effects

Radiation Oncology

Table 8 TCP-increase for different sensitivities of PET, high whole prostate dose, different α/β values, calculated α and low γ50(CN + 2 definition)

α [Gy^-1]	α/β [Gy]	γ50	Det. rate PET [%]	Dose [Gy]	SIB [Gy]	Single dose [Gy]	TCP_conv [%]	TCP Increase [%]
0.03	1.5	1.4	81	78	90	2	84.5	9.1
0.03	1.5	1.4	64	78	90	2	84.5	7.1
0.04	3.1	1.4	81	78	90	2	84.5	8.5
0.04	3.1	1.4	64	78	90	2	84.5	6.6
0.06	8.3	1.4	81	78	90	2	84.5	7.7
0.06	8.3	1.4	64	78	90	2	84.5	6.0

Calculation of the TCP-increase after boosting choline PET positive regions within the prostate up to 90 Gy, low homogeneous dose 78 Gy. α/β was set to either Fowler's/Wang's or Valdagni's result, α was analytically determined in order to achieve agreement between calculated TCD50 and TCD50 obtained by Cheung et al. γ50 was again taken from Cheung's data (CN + 2 definition).

ISSN: 1748-717X