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Table 7 TCP-increase for different sensitivities of PET, low whole prostate dose, different α/β values, calculated α and low γ50(CN + 2 definition)

From: Choline PET based dose-painting in prostate cancer - Modelling of dose effects

α [Gy-1] α/β [Gy] γ50 Det. rate PET [%] Dose [Gy] SIB [Gy] Single dose [Gy] TCPconv [%] TCP Increase
[%]
0.03 1.5 1.4 81 74 90 2 80 13.2
0.03 1.5 1.4 64 74 90 2 80 10.3
0.04 3.1 1.4 81 74 90 2 80 12.6
0.04 3.1 1.4 64 74 90 2 80 9.8
0.06 8.3 1.4 81 74 90 2 80 11.6
0.06 8.3 1.4 64 74 90 2 80 9.0
  1. Calculation of the TCP-increase after boosting choline PET positive regions within the prostate up to 90 Gy. α/β was set to either Fowler's/Wang's or Valdagni's value, α was analytically determined in order to achieve agreement between calculated TCD50 and TCD50 obtained by Cheung et al. γ50 was again taken from Cheung's data (CN + 2 definition).