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Table 7 TCP-increase for different sensitivities of PET, low whole prostate dose, different α/β values, calculated α and low γ50(CN + 2 definition)

From: Choline PET based dose-painting in prostate cancer - Modelling of dose effects

α [Gy-1]

α/β [Gy]

γ50

Det. rate PET [%]

Dose [Gy]

SIB [Gy]

Single dose [Gy]

TCPconv [%]

TCP Increase

[%]

0.03

1.5

1.4

81

74

90

2

80

13.2

0.03

1.5

1.4

64

74

90

2

80

10.3

0.04

3.1

1.4

81

74

90

2

80

12.6

0.04

3.1

1.4

64

74

90

2

80

9.8

0.06

8.3

1.4

81

74

90

2

80

11.6

0.06

8.3

1.4

64

74

90

2

80

9.0

  1. Calculation of the TCP-increase after boosting choline PET positive regions within the prostate up to 90 Gy. α/β was set to either Fowler's/Wang's or Valdagni's value, α was analytically determined in order to achieve agreement between calculated TCD50 and TCD50 obtained by Cheung et al. γ50 was again taken from Cheung's data (CN + 2 definition).