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Table 2 Comparisons of radiation induced transformation between MEFs of different genotypes vs. wild type MEFs.

From: Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis

 

Atm hz/Brca1 wt

Atm wt/Brca1 hz

Atm hz/Brca1 hz

Relative transformation (2 Gy)

1.8

1.66

1.88

t-test

P = 0.03

P = 0.05

P = 0.018

  1. Relative transformation is defined as the ratio of the number of transformed clones per surviving hemizygous cells relative to the number of transformed clones per surviving wild type cells. The statistical significance of differences in transformation frequency between the various cells with hemizygous genotypes and wild type cells was analyzed by the Student's t-test.